Chameleon Twist is a 3D platform game starring a blue chameleon named Davy as he travels across six themed worlds: Jungle Land, Ant Land, Bomb Land, Desert Castle, Kids Land, and Ghost Castle. The chameleon's elongated tongue can be used as a weapon, a means to traverse gaps, or as a way to leap onto platforms. Once the tongue is unrolled, it can be guided in any direction using the analog stick. A five-room training area is available to let you practice the unusual controls. The single-player game involves progressing through predominately indoor environments, each culminating in a boss battle, while collecting hearts to replenish health.
In addition to the single-player game, Chameleon Twist offers a battle option, allowing two to four players the chance to take part in either a Battle Royal or Time Trial event. Battle Royal has you trying to be the last chameleon left standing on a suspended platform, while Time Trial rewards the chameleon that stays on the platform the longest. In the latter event, the chameleon that has fallen off the fewest number of times is considered the winner. Options include four difficulty settings for multiplayer games, adjustable battle lengths, and a choice of four stages for both the Battle Royal and Time Trial modes.