After a high school student named Tomie (Miho Kanno) is murdered, a police investigation reveals a string of deaths--in which the victims were all named Tomie--dating back to the 1860s. Detective Harada (Tomoro Taguchi) finds clues in a classmate of Tomie's named Tsukiko (Mami Nakamura) who has no memory of the three months surrounding Tomie's death. Meanwhile, Tsukiko's former teacher has given birth to a strange humanoid creature that grows into a beautiful, oranged-eyed girl who responds to the name "Tomie." This bizarre Japanese horror entry, which has become a series, was based on the popular manga by Junji Ito.