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Acute Lung Injury: Epidemiology, Health Effects and Therapeutic Treatment Strategies by Daniela Mokra (Paperback, 2014)

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In this book, authors review the current knowledge on acute lung injury (ALI). ALI/acute respiratory distress syndrome (ARDS) is characterized by diffuse alveolar damage, alveolar capillary leakage, lung edema, neutrophil-derived inflammation, and surfactant dysfunction. These changes lead to clinical manifestations of decreased lung compliance, severe hypoxemia, and bilateral pulmonary infiltrates. In the first chapter the authors describe how two different models of multi-causality (intuitively appealing threshold model and abstract sufficient cause model), both of which are commonly used in the description of the etiology of diseases, can be applied to transfusion related acute lung injury (TRALI) and can both be used to describe the same observed relations between multiple risk factors and TRALI. In the second chapter, a dysfunction of the normal endothelialepithelial barriers and its role in the development of acute lung injury is described. Two leading pathogenic mechanisms of ALI are increased endothelial permeability and reduced alveolar liquid clearance capacity. Understanding of the fundamental mechanisms involved in the regulation of endothelial permeability is essential for the development of barrier protective therapeutic strategies. The following two chapters are focused on novel therapeutic strategies used in the treatment of ALI and more severe form acute respiratory distress syndrome (ARDS). Appropriate treatment involves protective lung ventilation, optimal fluid management, and pharmacological treatment. Despite that there are several possibilities of potentially beneficial pharmacotherapy of ALI/ARDS, the results of experimental and clinical studies are often controversial. The authors review the use of various pharmacological agents (including corticosteroids, neutrophil elastase inhibitors, anticoagulants, pulmonary vasodilators, antioxidants, methylxanthines, exogenous surfactant, gene-therapy, cell therapy, nitric oxide, myorelaxants, beta-agonists) and critically evaluate their effects in animal models and in patients with ALI/ARDS.

Product Identifiers

Publisher
NOVA Science Publishers INC International Concepts
ISBN-13
9781614704263
eBay Product ID (ePID)
209548491

Product Key Features

Author
Daniela Mokra
Publication Name
Acute Lung Injury: Epidemiology, Health Effects and Therapeutic Treatment Strategies
Format
Paperback
Language
English
Subject
Medicine
Publication Year
2014
Type
Textbook
Number of Pages
66 Pages

Dimensions

Item Height
230mm
Item Width
155mm
Item Weight
164g

Additional Product Features

Country/Region of Manufacture
United States
Editor
Daniela Mokra

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Acute Lung Injury: Epidemiology, Health Effects and Therapeutic Treatment Strategies by Daniela Mokra (Paperback, 2014)

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