Set between the second and third seasons of the modern animated series, Teenage Mutant Ninja Turtles: Danger of the Ooze finds gamers joining the acrobatic quartet as they try to stop Shredder and his mutant army from destroying New York. Players can switch between Donatello, Leonardo, Michelangelo, and Raphael at any time as they fight their way through nonlinear, side-scrolling levels, discovering new locations, and taking advantage of each character's unique abilities to earn experience to unlock upgrades.